An incense stick splinter is suspected to have triggered the fire.
The fire broke out in the afternoon on Monday, 2 Fire tenders were deployed to the site along with crew to extinguish the fire.
Properties worth lakhs of rupees were destroyed in the fire.
Fire tenders arrived at the spot and it took firefighters many hours before the blaze could be brought under control.
The incident took place around at 1:20 PM in the residential building at Thana Road, Shillong.
While three people have been rescued so far, several are still feared to be trapped in the building and some others injured.